![]() ![]() Magnetic resonance imaging scans were processed and analyzed as previously reported, ( DeCarli et al., 1992) by a reader blinded to the cases and controls’ demographic and clinical information. A total of 12 TGA cases and 41 controls were included in the study. Participants in the control group were seizure- and stroke-free at the match time, which was set as the date the TGA event occurred in the cases. Diagnostic criteria for TGA definition included: (1) acute onset of anterograde amnesia with or without a mild retrograde amnesia, (2) event witnessed, (3) no focal neurological deficits, (4) no alteration of consciousness, (5) resolution of symptoms within 24 h, (6) no loss of self identity, (7) no recent trauma or seizure, (8) no cognitive impairments other than amnesia, and (9) other causes of amnesia excluded.Ĭontrols were matched by FHS cohort, sex, year of birth, and attendance at the most recent FHS exam prior to the TGA episode. Transient global amnesia cases were ascertained using standard criteria ( Hodges and Warlow, 1990a) by a panel of neurologists. ![]() The present sample also included participants of the Offspring Cohort, which enrolled 5,124 participants in 1971. The Framingham Heart Study (FHS) is an ongoing longitudinal cohort study that began in 1948 and originally included 5,209 men and women to comprise the Original Cohort, and subsequently enrolled two additional generations. We studied this hypothesis by evaluating the association of TGA with traditional stroke risk factors, measures of subclinical brain ischemic injury on brain MRI, and subsequent stroke, TIA, and seizures in cases from a community-based sample. We hypothesized that TGA is related to ischemic cerebrovascular disease and may represent a risk factor for subsequent TIA and stroke. Although TGA is an uncommon disorder with mostly a benign course, ( Pantoni et al., 2005) the risk of subsequent neurological events is not entirely clear. The leading hypotheses to explain the pathophysiology of TGA involve epileptic causes, migraine, and cerebrovascular disease (i.e., ischemia, venous insufficiency). Patients appear confused, repeatedly asking orienting questions, but with sufficiently intact semantic, working, and procedural memory to be able to continue with everyday activities such as driving a car ( Logan and Sherman, 1983). Transient Global Amnesia (TGA) is a temporary anterograde amnestic syndrome characterized by the lack of other focal neurological signs or symptoms ( Hodges and Warlow, 1990a). However, our study is limited by small sample size and power, and larger studies are required to exclude an association. Extracranial vascular studies were negative for significant stenosis in all cases.Ĭonclusion: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. Electroencephalograms (EEG) ( n = 5) were negative for epileptiform activity. ![]() Head CT during the acute event ( n = 11) and brain MRI ( n = 7) were negative for acute abnormalities. Few incident stroke/transient ischemic attacks (TIA) (one event among the cases and four in controls) or subsequent seizures occurred in either group. ![]() Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample.ĭesign/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. TGA may be a risk factor for cerebrovascular or other neurological events. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. 3Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAīackground/objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits.2Framingham Heart Study, The National Heart, Lung, and Blood Institute, Framingham, MA, USA.1Department of Neurology, Boston University Medical Center, Boston MA, USA.José Rafael Romero 1,2* Melissa Mercado 1Īlexa S. ![]()
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